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Venlafaxine indirectly affects (mu-, kappa1- kappa3- and delta-opioid receptor subtypes) as well as the alpha2-adrenergic receptor, and was shown to increase pain threshold in mice.
After 4 weeks of treatment, most response rates among the drugs studied were similar.
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Duloxetine (Cymbalta) has greater potency in 5-HT reuptake inhibition than fluoxetine.
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Following promising early findings, more recent studies have reported inconsistent results, including findings that DCS resulted in faster rates of improvement but not higher response or remission rates in SAD and even more symptoms at post-treatment in PTSD.
Another group of the pharmaceutical compositions is transformed to a fluid composition just before the use and is then administered.
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